Nonalcoholic fatty liver disease (NAFLD), which is closely associated with obesity, has become the most common chronic liver disease in children and adolescents. The prevalence of pediatric NAFLD is 3% to 10% in normal-weight subjects and reaches a value of 80% in obese individuals. Patients and Methods: The present study included 200 diabetic patients developed to nonalcoholic fatty liver, recruited from Gastroenterology Outpatients Clinic in El Sahel Teaching Hospital. The study participants were divided into two groups: 100 healthy controls and 200diabetic patients with NAFLD (100 adults and 100 children). BMI: was calculated according to the following equation: weight (Kg) / height² (m²). Study population underwent fasting blood sampling to assess blood glucose (FBG), total cholesterol, HDL-cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total and direct bilirubin, INR, alpha-fetoprotein (AFP) and creatinine by biochemical laboratory methods. Interleukin 6(IL6), Tumor necrosis factor (TNF-α) and f Monocyte Chemoattractant Protein-1 (MCP-1) were analyzed by ELIZA. Results: This study showed highest sensitivity (88%) at MCP-1 level 309 ng/ml and highest specificity when compared with IL6 and TNF- α respectively (80%, 80% and 72%, 65%). The cutoff value of MCP-1equal 309 ng/ml above which the patient will develop to NALFD.
Keywords:Nonalcoholic fatty liver disease, Interleukin 6, Tumor necrosis factor, Monocyte Chemoattractant Protein-1